The Role of Stefin a in Breast Cancer Metastasis

Abstract

PUBLIC ABSTRACT It has been well established that distant metastases are responsible for most of the morbidity associated with breast cancer. To date, there is a lack of predictive markers to accurately determine whether a patient is likely to develop metastases and limited therapeutic options to prevent secondary tumor growth. For this reason, much effort is going towards elucidating the molecular mechanisms that govern breast cancer metastasis, from release of tumor cells from the mammary gland to adhesion and growth in a distant tissue/organ, such as the common sites of bone, lung, and liver. We have used a clinically relevant murine model of breast cancer metastasis, where a primary mamm..

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